Women are genetically predisposed to cellulite in comparison to men due to estrogen’s role in promoting fat storage and testosterone’s ability to break down fat cells. In women, the structure of collagen which is the main protein of connective tissue, has the appearance of a picket fence, whereas in men it looks like a crisscross pattern with a thicker band; therefore, the crisscross structure is much stronger which aids in keeping fat in place.

Another reason why women get cellulite related to two kinds of adrenergic receptors. When stimulated, alpha receptors constrict the blood vessels triggering the release of sugar into the bloodstream enabling fat cells to be stored. When beta receptors are stimulated increase the heart rate and dilate the blood vessels promoting the breakdown of fat. In women, there is a 1:9 ratio of alpha and beta receptors.